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Developing more refined in vitro and in vivo models that incorporate CYP3A4 metabolism, SLCO1B1-mediated transport, and oxidative stress pathways is essential to elucidate mechanisms and test targeted interventions
Oxidative stress has been identified as having an important role in cerebrovascular disease and given increasing recognition of the overlap between vascular dementia and AD (mixed dementia) and the contribution of vascular changes to AD [93] investigating potential effects of cerebrovascular disease as a covariate would be an important direction for future studies
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Its usually a symptom of something deeper hormonal decline, chronic inflammation, poor sleep quality, gut dysbiosis, or mitochondrial dysfunction
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